www.bewet.fora.pl

loczytzn

Metastasis suppressor gene discovery research

Identify the role of the order of M23. NM23 may encode a transcription factor of the high-tech communications 1993.1l is a surprising discovery, because the gene already has a very definite features. Three years ago, researchers at the Pasteur Institute in France, Lacombe and Wei Long found that the proteins encoded by these genes have NM23 nucleoside diphosphate (NDP) kinase function, NDP kinase through the phosphate from ATP into the corresponding diphosphate synthesis of GTP and the way the three other nucleoside phosphate. This is an unusual finding, because this protein not only has the enzyme, but also a transcription factor, \dual role of the protein species point of view, as this view may explain how changes in gene activity and changes in cell metabolism linked. For example, PuF/NM23 as a transcription factor may activate mye gene, which as a NDP kinase species may be provided out of the cell, DNA synthesis prior to the three nucleoside phosphate required. But Livingstone said the initial findings should be confirmed by further studies, because this finding was made in a test tube, which does not necessarily reflect the true effect of living cells in the process. If the initial findings are confirmed, we will be left is a problem: how to explain both the tumor suppressor gene NM23 is mye gene promoter. NCI researchers Patricia Lu Thai Ha Grid and colleagues first pointed out the characteristics of NM23 tumor suppressor genes. They discovered through animal experiments, increased expression of the gene appears to be accelerating the variation of tumor cells,[link widoczny dla zalogowanych], but will weaken the results of the transfer of cancer cells. Subsequently, NCI researchers human breast cancer cells were observed, the result has been a similar conclusion. However,[link widoczny dla zalogowanych], this mechanism of gene activity is still a mystery. Steiger Wei Lung Study Group and the research team found none of the high breast cancer cells with NDP kinase activity actually reduce cancer metastasis,[link widoczny dla zalogowanych], Wei Long Panel's findings would lead to the conclusion: NM23 gene may not be cancer metastasis suppressor gene. Steiger that, NM23 protein there are other kind of function, so that she had suppressed cancer metastasis. she felt. \The corresponding effect of NM23 relationship is not obvious. She pointed out that the anti-theory of a possible explanation is that PuF/NM23 transcription factor may be open other than the addition myc gene. However, in other types of cancer cells in the Lou by PuF/NM23 induced activation of myc genes is not surprising. of human breast cancer is, NM23 highly expressed in the patient's condition will be weakened,[link widoczny dla zalogowanych], but Steiger research group recently found in a human eye cancer - - neuroblastoma in the situation is quite the opposite. If you feel that the confusion caused by this discovery was not enough. then give you to raise a perplexing question: almost all cancer studies are directed NM23H1 transferred genes, The Postel found, PuF equivalent to a H2 NM23 gene. Hl variants may only play a role in cancer metastasis suppressor gene, despite that the two genes encoded by the protein's function is similar to 90. for trying to figure out mye mechanism of researchers, their most urgent hope is to confirm PuF/NM23 pre-myc gene transcription is a factor. \attribute this to the fact that in many different cells,[link widoczny dla zalogowanych], the gene by a number of different growth factors and other stimulating factors was opened to those who study this issue myc genes, a molecular biologist who has brought difficulties, despite the clone PuF explanation of the various test genes that regulate myc protein gene is indeed possible experiments. Livingstone said: \Even if not for mye PuF/NM23 control, its regulation of other genes of this or that is likely to remain important. \)

相关的主题文章：

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]