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Article by HOWARD AND COLLEAGUES1 in this issue of JAMA, which reports on the largest,most ambitious randomized dietary intervention trial conducted to date, has concluded that a low-fat diet program does not produce weight gain.1 Despite the impressive features of this landmark study, the findings on longterm weight change are somewhat underwhelming.
The Womens Health Initiative (WHI),2 of which the Dietary Modification Trial is one component [link widoczny dla zalogowanych],3 is one of the most outstanding achievements in clinical research history.The National Institutes of Health established the WHI in 1991 to address the most common causes of death, disability,and impaired quality of life in postmenopausal women.This multimillion-dollar, 15-year project, involving 161 808 women aged 50 through 79 years [link widoczny dla zalogowanych], was designed to address many of the inequities in womens health research and provide practical information to women and their physicians about hormone therapy,calcium/vitamin Dsupplements, dietary patterns, and prevention of heart disease,cancer, and osteoporosis.
The Dietary Modification Trial component evaluated the effect of a low-fat (target 20% fat), highfruit/vegetable and grain diet on the prevention of breast and colorectal cancer and heart disease. Between 1993 and 1998, 48 835 postmenopausal women with a mean baseline age of 62.3 years,mean body mass index of 29.1, and a dietary fat intake of at least 32% of total calories (approximately the 50th percentile for fat intake) were randomly assigned to either the self-selected dietary control group or the low-fat dietary intervention [link widoczny dla zalogowanych], which aimed to change dietary patterns but did not encourage weightloss or caloric reduction (even though the vast majority of participantswere obese or overweight). The trial did provide a unique opportunity to examine long-term effects of an ad libitumlow-fat dietary pattern on body weight and the relationships between weight changes and specific changes in dietary components. The authors reported a 2.2-kg weight loss in theintervention group at year 1 (1.9 kg between groups) and a modest 0.4-kg difference between the groups at the 7.5-year
mark (P=.01). They concluded that a low-fat eating pattern does not result in weight gain in postmenopausal women.1The article by Howard et al1 is quick to focus attention on popular diets such as Atkins,4 the Zone,5 and Sugar Busters!,6 whose authors have blamed the current obesity epidemic in large part on the low-fat (high-carbohydrate) eating pattern advocated by most authorities during much of the past quartercentury.7,8 Does the recent study refute allegations hat the low-fat dietary approach caused weight gain on a national scale? Perhaps it does to some extent. On the other hand, despite
some successes,9-12 overall the low-fat dietary approach has been a failure with the US public, which is in desperate need of effective
obesity treatment and prevention strategies.
Did the WHI trial designers miss an opportunity to choose a better dietary intervention? Should they have encouraged specific caloric reductions in verweight and obese women? The intervention group reported a significant reduction in total fat intake of 9 percentage points (38.8% to 29.8% of calories as measured by food frequency questionnaire)with little or no change in the control group, suggesting a rather successful dietary intervention (although
not close to the 20% target). But even though the women who reduced fat intake the most maintained some modest weight loss, absent an explicitly targeted caloric reduction this approach apparently had very little effect on mean body weight long term and presumably little effect on caloric intake.
Given what was known about nutrition at study inception,the low-fat, highfruit/vegetable and grain diet seems to have been a straightforward choice. The same cannot necessarily be said for the absent caloric restriction advice for overweight and obese participants. Weight loss was not a treatment goal, but perhaps it should have been.Is it time to admit defeat? Is US