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 Wysłany: Pią 4:06, 03 Gru 2010 Temat postu: true religion cheap Application of HSV-TK gene wit |
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Application of HSV-TK gene with adenovirus gene therapy of lung cancer
5,8 * I * shed the milk teeth, then the weight of the ship who grapefruit different mold rain red Geng: The HSV-TK gene with a cry of adenovirus-based cancer therapy Houses who were killing the cells has reached 75 or so; when infected with ADV / RSVtk of A549 cells in the total number of O cells, the cells were almost all anti-personnel. Thus, not only by the ADV / RSV-tk was killing only the infected cells. Virus-infected cells without some killed, the so-called bystander effect \This may be related to programmed cell death processes. flow cytometry and electron microscopy. found expression in the tk gene in tumor cells under the action of GCV,[link widoczny dla zalogowanych], appears cell shrinkage,[link widoczny dla zalogowanych], dense chromatin and other characteristics of programmed cell death and produce a kind of \Gene therapy in cancer based on the solid has a great future. References: LlJEzz ~ ddinezD border at.TheNew pumping, l991, 3 (6): 6082JChenSHetalMAcadUA, 1994,91:3054 [3] Wu Xiaobing life than learning, l994 .14 (5): 37L4JFreemaneta1.Reaearch,[link widoczny dla zalogowanych], 19g3, 53:5274 [53BalzariniJeta1 .., l993, 268 (9): 6332ResearchonHumanLungCancerGeneTherapybyRecombinantAdenoviruswithHSV-tk (receivedJanuaryI4, I996) GengYuhong, WaHaoquan, YingPeipei, XaRener,[link widoczny dla zalogowanych], WangYibin.ZhaoShouyuan.LiChangben '( StateKeyLab.ofGeneticEngineering, InstituteofGenetics, FudanUniversity, Shanghai200433) AbstractThekillereffectofadenovirusmediatedHSV-tkgeneandganciclovir (GCV) systemonhumanlungadenornacellsisreportedinthispaper.RecombinantadenovinaswithM.O.I (MultiplicityofInfection) of1000resultedinalmostl00A549celts (humanlungadenomacel1) death.BycomgaringMekillereffectondifferenthumanlung ~ tncercells (A549.LAX, SPCandSKY), itisfoundthatdifferenttransducedcelllineshavedifferentsusceptibilities.ThetransducedcellsaresusceptibletobothGCVandACVbutindifferentextents.ThekillereffectofGCVOilA549cellsjs7to8 a f0ldstrongerthanthatofACV . Thereisalsoa \
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